Infertility & Recurrent Miscarriage

Indications • Genetic Causes

Indications

PGD is recommended most frequently for patients with unexplained infertility, recurrent miscarriages, unsuccessful IVF cycles, advanced maternal age, or male factor infertility. The most likely cause is a chromosome abnormality. Chromosome abnormalities include aneuploidy and structural abnormalities. Aneuploidy is the most common chromosomal abnormality. Aneuploidy can occur in both eggs and sperm. Structural abnormalities include translocations, inversions, and deletions. Structural chromosome abnormalities can also be present in eggs and sperm. The transmission of a chromosome abnormality to an embryo can result in a low implantation rate, miscarriage or the birth of a baby with a genetic disorder. Using Fluorescence In Situ Hybridization (FISH), the scientists in our PGD laboratory can identify the absence of these specific genetic disorders in each normal developing embryo. As a result, only those embryos free of genetic disease will be transferred to the patient’s uterus so as to increase the chance of conception and ultimately a healthy baby.

Recurrent Miscarriage
Fertile couples wih repeated miscarriages should be evaluated for the presence of a chromosomal abnormality. The female or male partner may be a carrier of a balanced translocation or be an aneuploid mosaic.

Unsuccessful IVF cycles
Couples with repeated unsuccessful IVF cycles should be evaluated for the presence of a chromosome abnormality. The female or male partner may be a carrier of a balanced translocation or be an aneuploid mosaic.

Unexplained Infertility
The most probable cause of unexplained infertility or history of habitual miscarriage is a chromosome abnormality. The male OR female partner may be a carrier of a translocation or be an aneuploid mosaic.

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