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Preimplantation Genetic Diagnosis Program
The Center for Preimplantation Genetics Diagnosis
Preimplantation genetic diagnosis (PGD) is a state-of-the-art procedure used in conjunction with in vitro fertilization (IVF) to select embryos free of chromosomal abnormalities and specific genetic disorders for transfer to the uterus. These genetic conditions can interfere with embryo implantation, result in pregnancy loss, or in the birth of a child with physical problems, developmental delay, or mental retardation.
PGD may be recommended by your physician when there is a possibility, indicated by your medical history or advanced maternal age, that your embryos could be affected by a genetic disease. PGD testing can only be performed within the context of an IVF cycle where eggs and sperm, united in the laboratory, develop into embryos. The Center for Preimplantation Genetics, under the direction of Dr. William G. Kearns, offers PGD screening for chromosome disorders and single gene defects. Genetic testing on sperm from men with male factor infertility or those carrying a balanced translocation is also performed. The Center conducts research to evaluate and continually improve the clinical application of PGD and to develop new tests and genetic therapies to benefit a variety of patients.
Indications for PGD
Today, PGD technology reduces the potential for adverse pregnancy outcomes for couples ‘at risk’ by testing the embryos for certain genetic abnormalities before they are chosen for transfer back to the woman. For example: 10 embryos resulted from an IVF cycle and through PGD testing, six were identified as genetically abnormal and four were normal. Armed with this knowledge, only the normal embryos would be selected for embryo transfer thereby reducing the possibility of miscarriage or birth defects.
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